TIPRL Antibody, Biotin conjugated

Datasheet

Code	CSB-PA023569LD01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TIPRL Polyclonal antibody

Uniprot No.

O75663

Target Names

TIPRL

Alternative Names

1810011K17Rik antibody; dJ69E11.3 antibody; MGC3794 antibody; Putative MAPK activating protein PM10 antibody; Putative MAPK-activating protein PM10 antibody; RP1-69E11.1 antibody; Tip antibody; TIP41 antibody; TIP41-like protein antibody; tiprl antibody; TIPRL_HUMAN antibody; TOR signaling pathway regulator antibody; TOR Signaling Pathway Regulator like antibody; Type 2A-interacting protein antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human TIP41-like protein (1-178AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.

Gene References into Functions

overexpression of TIPRL promotes phosphorylation of H2AX, and increases gamma-H2AX positive foci in response to DNA damage, whereas knockdown of TIPRL inhibits gamma-H2AX phosphorylation PMID: 26717153
Unlike yeast TIP41, TIPRL has a positive effect on mTORC1 signaling through the association with PP2Ac. PMID: 23892082
Data indicate that PP2A holoenzyme biogenesis and activity are controlled by five PP2A modulators, consisting of alpha4, PTPA, LCMT1, PME-1 and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled. PMID: 22443683
TIPRL is highly up-regulated in human HCC samples and cell lines, compared with noncancerous liver tissues. PMID: 22841785
Observational study of gene-disease association. (HuGE Navigator) PMID: 19536175
Observational study of gene-disease association. (HuGE Navigator) PMID: 19064610

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Subcellular Location

Cytoplasm.

Protein Families

TIP41 family

Database Links

HGNC: 30231

OMIM: 611807

KEGG: hsa:261726

STRING: 9606.ENSP00000356807

UniGene: Hs.209431

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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